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With an estimated population of 467,605 in 2012, Greenville County is South Carolina's largest county. The County’s population has increased by 87,989 since 2000 or 1.9% per year. Greenville is one of the ten counties that comprise the Upstate Region of South Carolina. The Upstate’s population has been steadily increasing, growing from 1,220,516 in 2000 to 1,384,996 in 2012, a 1.2 percent annual increase since 2000. The Greenville MSA population (Greenville, Laurens and Pickens County) has grown from 559,940 in 2000 to 653,498 in 2012, a 1.4 percent increase per year during that time period. Profile of General Demographic Characteristics
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| Subject | Estimate | Percent |
| Total Population | 451,225 | |
| Gender | ||
| Male | 223,977 | 49.6% |
| Female | 227,248 | 50.4% |
| Age | ||
| Under 10 | 61,056 | 13.5% |
| 10 to 19 | 60,794 | 13.5% |
| 20 to 34 | 90,551 | 20.1% |
| 35 to 54 | 128,138 | 28.4% |
| 55 to 64 | 53,105 | 11.7% |
| 65 and older | 57,581 | 12.8% |
| 20 to 64 | 271,794 | 60.2% |
| Median Age (2010) | 37.2 | |
| Race | ||
| White | 333,084 | 73.8% |
| Black | 81,497 | 18.1% |
| Asian | 8,849 | 2.0% |
| Amer. Indian / Alaskan | 1,401 | 0.3% |
| Two or More Races | 8,470 | 1.9% |
| Hispanic or Latino | 36,495 | 8.1% |
Population Growth, 2000 - 2012
| Region |
2000 Population |
2012 Population |
Population Increase 2000-2012 |
% Annual Increase
2000-2012 |
| Greenville County |
379,616 |
467,605 |
87,989 | 1.9% |
| Greenville MSA |
559,940 |
653,498 |
93,558 | 1.4% |
| Upstate SC Region |
1,220,542 |
1,384,996 |
164,454 | 1.2% |
| South Carolina |
4,012,012 |
4,723.723 |
711,711 | 1.5% |

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