View Greenville, SC & Biopharma Brochure
FLUOR Completes Biotech Manufacturing Layout for Matrix Park
Fluor's Life Sciences Group has recently completed a conceptual biotech manufacturing layout for a 190 acre site at the Matrix Business & Technology Park. Commissioned by the GADC, the design includes 2 bulk cell culture API manufacturing facilities, a bulk API fill & finish facility, an R&D facility and room for potential clinical scale manufacturing.
To view the conceptual site layout, click here.
For an explanation of the design, click here.
Local, Regional & State Intellectual Resources in Support of Pharmaceutical & Biotechnology Companies - Greenville, South Carolina
LOCAL
Dr. Tom Wagner, Greenville Hospital System’s Oncology Research Center
A pioneer in the biotechnology industry, Dr. Wagner started 3 successful biotechnology companies: DNX, Diagnostic Hybrids and Progenitor. Further, while at the University of Ohio, he was the first scientist to introduce foreign genes into a higher species generating the world’s first transgenic animal (no immune system). In addition, he headed the State of Ohio's biotechnology initiative. Today, as the head of Greenville Hospital’s Oncology Research Center, he and his staff are researching and have made unique discoveries toward the cures for melanoma, breast cancer, and prostate cancer. With unique access to over 1,100 beds for human trials, the Center will develop new drugs taking them up to the manufacturing stage of development. www.ghs.org/362/index.aspx
Greenville Hospital System/Clemson University Biomedical Cooperative
This initiative links Clemson’s expertise in biomedical research with the clinical expertise of the hospital system to advance knowledge of clinical and biomedical sciences and then foster the application of that knowledge to the practice of medicine. Research teams include laboratories for Medicinal Chemistry, Molecular Endocrinology, Vascular Research, and Tumor Biology and Human Pathology.
REGIONAL
Clemson University
The Department of Genetics & Biochemistry
Research programs focus on human, animal, plant, microbial, molecular and biometrical genetics. Biochemical research areas include plant hormones and nodulation, desaturases of plant biomembranes, DNA repair, protein engineering, signal transduction in mammalian cell systems, and biochemistry of cellular stress in plants and animals. Specialized research laboratories include a DNA sequencing facility, a monoclonal antibody facility, a computerized bioinstrumentation laboratory, an image analysis facility, a confocal/electron microscopy suite equipped for transmission and scanning electron microscopy, controlled-environment chambers, a tissue culture laboratory, fully equipped darkrooms, isotope handling and counting facilities, plant growth chambers, a greenhouse, and a small-animal care facility with surgical capabilities. Clemson is the 1st University in state to offer an undergraduate degree in Genetics – Fall 2003. www.clemson.edu/genbiochem
The Department of Bioengineering
Started in 1963 and recognized as having pioneered the field of Biomaterials, Clemson University's Bioengineering Department is one of the oldest in the world. Research emphases are biomaterials, biomechanics and cellular biology, particularly for orthopedic and cardiovascular applications. Other research specialties include cell biology and tissue engineering; the development of new implant materials; in vivo performance of biomaterials; the biological response to implanted biomaterials; biomechanics of tissue, implants, and the tissue/implant interface; wear and lubrication of joints; spinal mechanics; visualization techniques; CAD/CAM-based custom prostheses design; and electrical stimulation for bone and wound healing. http://www.ces.clemson.edu/bio
Clemson Institute of Environmental Toxicology (CIET)
The CIET is a 38,000 square-foot facility with state-of-the-art labs having computer-controlled environments and specialized testing rooms for its 11 faculty members and 29 graduate students. Research encompasses the areas of aquatic ecotoxicology, biochemical and molecular toxicology, immunobiology and immunotoxicology, development of antimicrobial resistance in populations, terrestrial ecotoxicology, analytical chemistry, and ecological modeling. A strong fundamental research program at CIET examines the mechanisms of how chemicals exert their toxicity and how variability in individual organisms can lead to sensitivity or resistance in a wide array of species. www.clemson.edu/entox/about/index.htm
Clemson University Genomics Institute (CUGI)
CUGI is dedicated to research and training focusing on the discovery and functional analysis of important genes from crop plants (such as corn, cotton, rice, and tomato), crop pests, and environmentally important tools using the specialized tools of Genomics. In addition, they are producing the libraries and DNA sequence of genetic materials needed to understand the molecular biology of plants. Goals include the development of vitamin-enhanced crops; edible vaccine; and fuels, chemicals and plastics produced from renewable plant resources. www.genome.clemson.edu
Godley-Snell Research Center (GSRC)
The GSRC is a 22,000 square foot transgenic animal research facility having AAALAC accreditation. With full environmental controls and monitored using the Edstrom system, it contains a fully outfitted biocontainment suite that meets CDC Animal Biosafety Level 3 criteria, a central surgical facility, a nursing station, a sterile prep room and a radiology room. www.clemson.edu/research/orssite/orsfaclts_GSRC.htm
Biosytems Research Complex
The Biosystems Research Complex is a multimillion-dollar agricultural biotechnology and molecular biology research complex and will be a vehicle for Clemson to partner with biotechnology companies to develop and implement commercial applications of desirable genetic properties through research and technology transfer programs. www.virtual.clemson.edu/groups/agbioeng/
DNA Learning Center
In partnership with the Cold Spring Harbor Laboratory, Clemson will establish a South Carolina DNA Learning Center with the goal of engaging the South Carolina public in a balanced, scientifically sound education program for modern genetics and biotechnology. This will include such activities as increasing the number of K-12 teachers with a basic competency in biotechnology, preparing students to enter 21s century careers in biotechnology, and educating the general public.
Biotechnology/Pharmaceutical Recent Successes
· Discovering the molecular connection between dietary fat and breast cancer.
· Isolating the pharmaceutically active ingredients in herbal medicines such as Echinacea, Gingko, and St. John’s Wart.
· Devising longer-lasting knee implants.
· Designing an improved intravascular device to keep clogged arteries open.
· Designing spinal implants with the promise of pain-free mobility.
SC Biotechnology Incubation Facility
Designed to assist biotech entrepreneurs, this 22,000 square-foot facility contains six incubation modules, each containing wet labs and office space with access to with conference facilities and library resources. The incubator will lease space to new and early-stage companies as well as provide shared support and staff with expertise in intellectual property rights, research grants, business plan development and financing. www.ggc.org/biotechnology.htm
Greenwood Genetics Center/J.C Self Research Institute of Human Genetics (GGC)
The GGC has been working since 1974 to diagnose and study genetic conditions. Its diagnostic laboratories offer comprehensive and state-of-the-art genetic testing in biochemistry, cytogenetics, molecular genetics and prenatal screening. With some 20 world-class MD/PhD geneticists on staff, the center is at the forefront of research into the causes of genetic diseases. www.ggc.org/biotechnology.htm
STATE
The South Carolina Research Authority (SCRA)
The SCRA is a non-profit corporation of South Carolina’s key corporate, government and university leaders created to stimulate economic growth through science and technology by providing resources and expertise to assist corporations in achieving their corporate objectives. Goals include attracting advanced technology, strengthening partnerships between academia and industry, moving emerging technology into companies, and teaming with technology leaders to engage in competitive research. www.scra.org
Medical University of South Carolina –
MUSC’s College of Pharmacy established the Pharmaceutical Development Center (PDC) in 1979 to conduct contractual development services for the pharmaceutical industry. Along with this state-of-the-art cGMP facility, MUSC has a Biotechnology Research Lab and a transgenic animal facility. Further, the Medical University is under contract with over 100 business partners and has licensed technology to over 25 life science companies. http://brin.sc.edu
University of South Carolina
USC is the lead research institution for the Biomedical Research Information Network, a statewide consortium to coordinate new biomedical research opportunities, forge relationships with other researchers, upgrade laboratories, and provide seminars and other programs for scientists. In addition, USC recently received an $11 Million grant from the National Institute of Heath for the study of colorectal cancer and will establish a Center for Colon Cancer Research. www.cosm.sc.edu/biotech
National Nutraceutical Center
As a collaborative project between Clemson University, the Medical University of South Carolina, the SC Research Authority, and several nutraceutical companies, the NNC is dedicated to researching and developing medicinal plants to provide nutraceuticals for consumer use. Efforts include research on plant production and processing as well as clinical trials on product safety and efficacy. www.clemson.edu/scg/nutrac/detail.htm
MORE RESOURCES
For more information on why South Carolina is the right environment for the Pharmaceutical and Biotech Industry, Click here.
